Science

New Study Concludes mRNA In Pfizer Shot Can Be Reverse Transcribed Into Human DNA

This study published by researchers from Sweden was done in vitro and performed on a human liver cell line.

By Arjun Walia | The Pulse

recent study out of Sweden has presented evidence showing that the mRNA contained in the Pfizer COVID vaccine can be reverse transcribed into human DNA. The study was done in vitro and performed on a human liver cell line. This suggests that the pathogen does what HIV and other retroviruses do and have done, integrate its genetic code, or parts of it, into the human genome, but there are still many unanswered questions.

Normally, DNA is transcribed or copied to RNA and then translated to protein. Reverse transcriptase as it’s referred to, copies RNA back to DNA. This type of activity is needed for function in viruses. In viruses, reverse transcriptase allows the virus to insert its DNA into the host cell’s DNA, forcing the cell to make more virus. This is good for the virus but bad for the host.

A paper published in Viruses, Essential Agents of Life in 2012 explains,

“Upon cell infection, some viruses integrate their genome into the host chromosome, either as part of their life cycle (such as retroviruses), or incidentally. While possibly promoting long-term persistence of the virus into the cell, viral genome integration may also lead to drastic consequences for the host cell, including gene disruption, insertional mutagenesis and cell death, as well as contributing to species evolution.”

But it may not always be a bad thing. Who knows, viruses make up a large portion of our genome and we have viruses inside of us that our ancient ancestors had transcribed into their DNA. Some of these viruses that have been integrated into our genome from the past may be protecting us, others may be hurting us and increasing our risks for various diseases, like cancer for example. But I digress. It’s hard to know what, if any, difference there is between a natural COVID infection doing this, and let’s say the vaccine induced spike protein which our cells are instructed to produce.

What may be a point of concern is the fact that the mRNA molecules via gene based vaccines have been deliberately manipulated to become more stable once inside the cell. A “pseudouridine” molecule has been added to the mRNA to give it a longer half-life than normal mRNA. Therefore, the production of spike protein within the cell is not being turned off. We don’t know the implications of this.

The motivation for the study seemed to be, as outlined in the paper, pharmacokinetics data provided by Pfizer to the European Medicines Agency (EMA) that the researchers site. The Japanese government also released this biodistribution data.

It showed that the biodistribution of the vaccines contents was studied in mice and rats. mRNA lipid nanoparticles showed that a portion of the vaccines content ended up in the liver (18%) as well as various other organs in the body. This is why the Swedish researchers chose to investigate the effects of the Pfizer vaccine on a human liver cell line.

According to the authors,

“We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 hours upon BNT162b2 exposure.”

This study comes after a previous study published last May that showed RNA from a natural COVID infection can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. So it’s not hard to see why researchers wanted to examine if this is true with regards to the vaccine as well.

These findings may also explain why many people who test “positive” may not actually be infectious. The test may simply be picking up parts of the virus that have integrated into peoples genome. The PCR assays may detect viral transcripts that derive from viral DNA sequences that have been integrated into the genome rather than infectious virus.

The authors explain and reiterate their results,

“Our results showed that BNT162b2 mRNA readily enters Huh7 cells at a concentration (0.5 µg/mL) corresponding to 0.5% of the local injection site concentration, induce changes in LINE-1 gene and protein expression, and within 6 hours, reverse transcription of BNT162b2 can be detected.”

LINE-1 retrotransposition is a major hallmark of cancer and genomic instability/DNA damage. A review article published in Frontiers in Cell Development and Biology explains,

“Efficient retrotransposition of LINE-1 is often associated with cell cycle and nuclear envelope breakdown during mitosis [52,53], as well as exogenous retroviruses [54,55], which promotes entrance of LINE-1 into the nucleus.”

LINE-1 elements are remnants of ancient retroviral infections and make up about 17% of the human genome, and what happens here can either contribute to or hinder human health various ways.

It’s noteworthy to mention that a study published in Oct 2021 shows that spike protein “significantly inhibits DNA damage repair” in a laboratory cell line.

Furthermore, biodistribution data mentioned above is also available in humans. A study showed that spike protein could be detected in the blood of 11 of the 13 participants following vaccination with the Moderna mRNA vaccine.

The authors of the Swedish study explain, “To better understand mechanisms underlying vaccine-related adverse effects, clinical investigations as well as cellular and molecular analyses are needed.”

Perhaps studies like this can help explain some of the underlying mechanisms as to why so many COVID vaccine injuries have been reported.

I recently published an article discussing if the spike protein is “toxic”, and what differences there are between the spike protein that gene based vaccines instruct our cells to make and the natural version. That article goes into concerns regarding the integrity of the cell and if what’s happening inside of it as a result of the production of the spike protein can impact the nucleus.

There are so many unanswerable questions among experts in the field. I am grateful for the opportunity to at least express myself, explore and ask questions, something that’s increasingly becoming frowned upon.

This article (New Study Concludes mRNA In Pfizer Shot Can Be Reverse Transcribed Into Human DNA) was originally published on The Pulse and is published under a Creative Commons license.

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